08 Jul Date July 8, 2024 Author rbanhlab Tags Dioxygenase, Gaseous Labeling, HPDL, Metabolism, Pancreatic Cancer The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. Nature. (2021). 597 (7876), 420-425. Banh R.S., Kim E.S., Spillier Q., Biancur D.E., Yamamoto K., Sohn A.S.W., Shi G., Jones D.R., Kimmelman A.C., Pacold M.E....
08 Jul Date July 8, 2024 Author rbanhlab Tags Autophagy, Metabolism, Pancreatic Cancer, Signal Transduction Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11. PNAS. (2021). 118 (6) e2021475118. Mukhopadhyay S., Biancur D.E., Parker S.J., Yamamoto K., Banh R.S., Paulo J.A., Mancias J.D., Kimmelman A. C....
08 Jul Date July 8, 2024 Author rbanhlab Tags Functional Genomics, in vivo Screen, Metabolism, Pancreatic Cancer Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer. Cell Metabolism. (2020). S1550-4131(2), 30551-9. Biancur D., Kapner K., Yamamoto K., Banh R.S., Neggers J.E., Sohn A. S. W., Wu W., Manguso R., Brown A., Root D., Aguirre A. J., K...
08 Jul Date July 8, 2024 Author rbanhlab Tags Codons, Metabolism, mRNA Translation, Neurons, Pancreatic Cancer Neurons release serine to support mRNA translation in pancreatic cancer. Cell. (2020). 183(5), 1202-1218. Banh R.S., Biancur D., Yamamoto K., Sohn A. S. W., Walters B., Kuljanin M., Gikandi A., Wang H., Mancias J. D., Schneider R. J., P...
08 Jul Date July 8, 2024 Author rbanhlab Tags Autophagy, Immunotherapy, MHC-I, Pancreatic Cancer, T-cells Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. (2020). 581, 100-105. Yamamoto K., Venida A., Yano J., Biancur D. E., Kakiuchi M., Gupta S., Sohn A. S. W., Mukhopadhyay S., Lin E. Y., Parker S. J., Ba...
08 Jul Date July 8, 2024 Author rbanhlab Tags Dioxygenase, DNA methylation, Epigenetics, Leukemia Restoration of TET2 function blocks aberrant self-renewal and leukemia progression. Cell. (2017). 170, 1079-1095. Cimmino L., Dolgalev I., Wang Y., Yoshimi A., Martin G.H., Wang J., Ng V., Xia B., Witkowski M. T., Mitchell-Flack M., Grillo I.,...
07 Jul Date July 7, 2024 Author rbanhlab Tags Breast Cancer, Hypoxia, Protein Tyrosine Phosphatase, Signal Transduction PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nature Cell Biology. (2016). 18, 803-813. Banh R. S., Iorio C., Marcotte R., Xu Y., Cojocari D., Rahman A. A., Pawling J., Zhang W., Sinha A., Rose R.M., Isasa M., Zhang S....